Protein Production
Axela’s technologies have demonstrated direct applications for protein expression and purification monitoring for use in biotherapeutic and general protein and antibody production currently performed in biopharma, CMO’s and diagnostics manufacturers. Researchers in these areas are involved in:
- Multiplex quantitation of target recombinant protein and host cell contaminants throughout the biopharmaceuticals manufacturing process
- Improving efficiency with real time results, and active concentration measurements
- Point-of-production protein monitoring
- Protein production in a regulated environment
And who need:
- Protein production information in real-time in order to monitor and make immediate adjustments to the production process
- The ability to rapidly analyze samples as soon as they are obtained
- Broad dynamic range
- Assays that recognize only the functionally active protein
- 21 CFR Part 11 Compliance Support
Applications
dotLab mX System
Determination of >7 logs of protein concentrations on single samples
Real-time protein characterization
Contaminant Monitoring
Antibody pairing for assay development
21 CFR Part 11 Compliance Support, including:
- Secure Database
- Audit Trail
- Signature controls
- User/Password Controls
Ziplex System
High content protein assays and pathway screening
Multiplex antigen host cell protein analysis
The Axela Advantage
- Performs assays that recognize only the functionally active protein
- One platform for development of validated assays and transferable SOPs between labs
- Allows for immediate process monitoring and modifications to improve productivity and yield