Literature
A. Brochures
Information Brochures
- Breast Cancer Xpress Chips Product Information [PDF]
- Colon Cancer Xpress Chips Product Information [PDF]
- Diffractive Optics Technology – dot® (Technology Brief ) [PDF]
- dotLab mX System Brochure [PDF]
- Inflammation Xpress Chips Product Information [PDF]
- Metabolic Xpress Chips Product Information [PDF]
- panelPlus Brochure [PDF]
- Ziplex System Brochure [PDF]
B. Oncology Applications
Oncology/Translational Research
- A 43-gene gene expression array for profiling of clinical samples in the development and validation of a breast cancer recurrence test (Poster) [PDF]
- Biomarker Translation from Global Expression Arrays to Focused Arrays (Application Brief) [PDF]
- Biomarker Translation from Global Expression Arrays to Focused Arrays on the Ziplex System (Whitepaper) [PDF]
- The chemiluminescence based Ziplex® automated workstation focus array reproduces ovarian cancer Affymetrix GeneChip® expression profiles – Michael CJ Quinn, Daniel J Wilson, Fiona Young, Adam A Dempsey, Suzanna L Arcand, Ashley H Birch, Paulina M Wojnarowicz, Diane Provencher, Anne-Marie Mes-Masson, David Englert, Patricia N Tonin, Journal of Translational Medicine 2009, 7:55 (6 July 2009) (Article)
C. Immune Status
Infectious Diseases
- Development of a Rapid Serological Assay for Strongyloides Infection Using Diffraction-Based Optical Biosensors (Whitepaper) [PDF]
- Development of Rapid and Sensitive Serological Assays (Application Brief) [PDF]
- Proteomic TipChip for High Speed Serology (Application Brief) [PDF]
- Rapid Triplex Serology Assay on panelPlus Sensors (Application Brief) [PDF]
- Ziplex System & Proteomic TipChip for High Speed Serodiagnostics of Infectious Disease (Whitepaper) [PDF]
Titer and Avidity
- Characterization of Vaccine-Induced Immune Responses Using a Novel Diffractive Optics Technology (Poster) [PDF]
- Rapid Determination of IgG Titer and Avidity (Application Brief) [PDF]
- Rapid Determination of IgG Titer and Avidity Using Optical Diffraction (Whitepaper) [PDF]
Direct Pathogen Detection
- Detection of E. coli Bacteria by Diffractive Optics (Application Brief) [PDF]
- Direct Pathogen Detection by Diffractive Optics (Whitepaper) [PDF]
- Influenza Virus Detection on Nasal Swab Samples (Application Brief) [PDF]
D. Specialty Applications
Traumatic Brain Injury
- Analysis of Traumatic Brain Injury Biomarkers on the Ziplex System (Application Brief) [PDF]
- Quantitative Assay for Rapid NSE Detection (Application Brief) [PDF]
- Rapid Conversion of NSE ELISA to Diffraction Based Immunoassay (Whitepaper) [PDF]
Cardiac Troponin
- Development of a novel diffraction based immunoassay for characterizing the primary and ternary structure of the circulating form of cardiac troponin (Whitepaper) [PDF]
- Development of a Qualitative Sequential Immunoassay for Characterizing the Intrinsic Properties of Circulating Cardiac Troponin I – Yixin Lin, Qin Fu, Jie Zhu, Julie M. Miller, and Jennifer E. Van Eyk. Journal of Clinical Chemistry. 2010 May 28; 56(8):1307-1319. doi:10.1373/clinchem.2009.135186. (Article)
Other
- Identifying a Diagnostic Classifier of CdLS by a Step-wise Multi-platform Procedure (Poster) [PDF]
- Transcriptional dysregulation in NIPBL and cohesin mutant human cells. – Jinglan Liu, Zhe Zhang, Masashige Bando, Takehiko Itoh, Matthew A. Deardorff, Dinah Clark, Maninder Kaur, Stephany Tandy, Tatsuro Kondoh, Eric Rappaport, Nancy B. Spinner, Hugo Vega, Laird G. Jackson, Katsuhiko Shirahige, and Ian D. Krantz. PLoS Biology. 2009 May 26;7(5):e1000119. doi:10.1371/journal.pbio.1000119. (Article)
E. Assay Development
Real Time Immunoassays
- A Novel Approach to Label-Free Sensing: Diffractive Optics Technology (dot®) – JF Houle, Comb Chem High Throughput Screening, (2009), 12, 801-811. Access required (Article)
- Antibody Isotype Determination (Application Brief) [PDF]
- Development of a Multiplex Ovarian Cancer Biomarker Assay (Application Brief) [PDF]
- Extended Dynamic Range during Multiplex Analysis (Application Brief) [PDF]
- Extended Dynamic Range on Multiplex panelPlus® Sensors (Application Brief) [PDF]
- Identification of Spurious Signal in Immunoassays Due to Serum Antibodies Against Blocking Proteins (Poster) [PDF]
- Label-free and amplified quantitation of proteins in complex mixtures using diffractive optics technology – S. Cleverly, I. Chen, J-F Houle, J. Chromatography B, 878 (2010) 264-270 (Article)
- Protein Detection and Quantitation by Diffraction-based Immunoassay (Application Brief) [PDF]
- Rapid and Improved Immunoassay Development and Optimization Using the dotLab® mX System (Whitepaper) [PDF]
- Rapid Development and Optimization of Immunoassays by Diffractive Optics (Application Brief) [PDF]
- Solving the multiplexing-dynamic range conundrum with Diffractive Optics Technology (dot™); Nature, Nature Methods, January 2007 (Article) [PDF]
- Versatile and Customizable Multiplexed Assays Using Optical Diffraction (Whitepaper) [PDF]
Flow Thru Microarrays
- Flow-through microarrays for rapid biomarker testing – Medical Laboratory Observer, April 2013 (Article)
- Gene Expression Profiling on the Ziplex® System Demonstrates High Inter-platform Concordance (Whitepaper) [PDF]
- New Technologies for FFPE Samples: Improved RNA Isolation and novel cDNA priming for qPCR and for universal mRNA amplification (Poster) [PDF]
- System Verification of Ziplex®, a multiplex gene expression system for translational research and clinical diagnostics (Poster) [PDF]